Pemphigus versus pemphigoid, dermatitis herpetiformis, Stevens-Johnson and toxic epidermal necrolysis, DRESS, erythema multiforme and immunofluorescence patterns.
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- What is the primary autoantibody target in pemphigus vulgaris?
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Desmoglein 3 (often with desmoglein 1 in mucocutaneous cases)- At what level of the epidermis does blistering occur in pemphigus vulgaris?
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Suprabasal, within the epidermis (intraepidermal split)- What histologic sign describes basal keratinocytes that remain attached to the dermis but detach from each other in pemphigus vulgaris?
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Row of tombstones sign- Which mucosa is commonly the first site affected in pemphigus vulgaris?
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Oral mucosa- What term describes the loss of keratinocyte cell to cell adhesion that causes blister formation in pemphigus?
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Acantholysis- Is the Nikolsky sign positive or negative in pemphigus vulgaris?
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Positive- What is the primary autoantibody target in pemphigus foliaceus?
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Desmoglein 1- At what level of the epidermis does blistering occur in pemphigus foliaceus?
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Superficial epidermis, in the granular layer (subcorneal split)- Is mucosal involvement common in pemphigus foliaceus?
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No, the mucosa is usually spared- What direct immunofluorescence pattern is characteristic of pemphigus (both vulgaris and foliaceus)?
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Intercellular IgG deposits in a net-like, fishnet pattern between keratinocytes- What are the two main autoantibody targets in bullous pemphigoid?
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BP180 (BPAG2) and BP230 (BPAG1)- At what level of the skin does blistering occur in bullous pemphigoid?
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Subepidermal, at the dermal-epidermal junction- Describe the typical appearance of bullous pemphigoid lesions.
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Tense bullae arising on an erythematous or urticarial base- Which age group is most commonly affected by bullous pemphigoid?
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Elderly patients- Is the Nikolsky sign positive or negative in bullous pemphigoid?
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Negative
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