A condensed rapid review pass over the highest yield pulmonary pathology and physiology facts for final week review.
About this set
40 mixed cards for USMLE Step 1 Pulmonology. It opens with "In obstructive lung disease, the FEV1/FVC ratio is ____" and "In restrictive lung disease, the FEV1/FVC ratio is ____". Study it alongside the other USMLE Step 1 sets below.
40 cards · mixed cards · AI-written, checked twice. Edit anything.
- In obstructive lung disease, the FEV1/FVC ratio is ____.
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decreased- In restrictive lung disease, the FEV1/FVC ratio is ____.
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normal or increased- What is the clinical definition of chronic bronchitis?
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Productive cough for at least 3 months per year, for 2 consecutive years- In emphysema, what lung structure is destroyed?
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Alveolar walls (airspaces distal to the terminal bronchiole)- How does alpha-1 antitrypsin deficiency cause emphysema?
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Unopposed neutrophil elastase destroys alveolar walls- Panacinar emphysema is classically associated with what condition?
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Alpha-1 antitrypsin deficiency- Centriacinar (centrilobular) emphysema is most strongly associated with what exposure?
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Cigarette smoking- Airway obstruction in asthma is driven by what type of hypersensitivity reaction?
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Type I (IgE-mediated) hypersensitivity- What are Curschmann spirals, found in asthmatic sputum?
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Spiral-shaped mucus plugs from small airways- Charcot-Leyden crystals in asthma sputum are derived from which cell type?
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Eosinophils- How is bronchiectasis defined structurally?
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Permanent, abnormal dilation of the bronchi and bronchioles- Cystic fibrosis is caused by mutation in which gene?
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CFTR- The CFTR gene is located on chromosome ____.
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7- What is the most common CFTR mutation causing cystic fibrosis?
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Delta F508 (deletion of phenylalanine at position 508)- What classic high-resolution CT finding is seen in idiopathic pulmonary fibrosis?
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Honeycomb lung (subpleural cystic changes)
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