Lupus, rheumatoid arthritis, scleroderma, and other connective tissue diseases with their hallmark clinical and lab findings.
35 cards · basic cards · AI-written, checked twice. Edit anything.
- What skin finding is classic for SLE and is worsened by sun exposure?
- Malar (butterfly) rash
- Which antibody test is highly sensitive but not specific for SLE?
- ANA (antinuclear antibody)
- Which antibody is specific for SLE and correlates with lupus nephritis activity?
- Anti-double-stranded DNA (anti-dsDNA)
- Which antibody is specific for SLE but does not track with disease activity?
- Anti-Smith (anti-Sm) antibody
- Which antibody is characteristic of drug-induced lupus?
- Anti-histone antibody
- Name three drugs classically associated with drug-induced lupus.
- Hydralazine, procainamide, and isoniazid
- What cardiac lesion in SLE features sterile vegetations on both sides of the valve leaflets?
- Libman-Sacks endocarditis
- What is the most common and severe class of lupus nephritis?
- Diffuse proliferative glomerulonephritis
- Name three antibodies associated with antiphospholipid syndrome.
- Anticardiolipin, lupus anticoagulant, and anti-beta2 glycoprotein I
- Why can antiphospholipid syndrome cause a false-positive VDRL/RPR test?
- The antiphospholipid antibodies cross-react with the cardiolipin antigen used in the test
- What are the two hallmark clinical features of antiphospholipid syndrome?
- Recurrent thrombosis and recurrent pregnancy loss
- What inflamed synovial tissue erodes joints in rheumatoid arthritis?
- Pannus
- Which antibody is most specific for rheumatoid arthritis?
- Anti-cyclic citrullinated peptide (anti-CCP)
- What is rheumatoid factor?
- An IgM antibody directed against the Fc portion of IgG
- Which finger joints are involved in rheumatoid arthritis, and which are spared?
- MCP and PIP joints are involved; DIP joints are spared