Lupus, rheumatoid arthritis, scleroderma, and other connective tissue diseases with their hallmark clinical and lab findings.
About this set
35 basic cards for USMLE Step 1 Musculoskeletal and Dermatology. Set 2 of 4 in USMLE Musculoskeletal. It opens with "What skin finding is classic for SLE and is worsened by sun exposure?" and "Which antibody test is highly sensitive but not specific for SLE?". Study it alongside the other USMLE Step 1 sets below.
35 cards · basic cards · AI-written, checked twice. Edit anything.
- What skin finding is classic for SLE and is worsened by sun exposure?
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Malar (butterfly) rash- Which antibody test is highly sensitive but not specific for SLE?
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ANA (antinuclear antibody)- Which antibody is specific for SLE and correlates with lupus nephritis activity?
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Anti-double-stranded DNA (anti-dsDNA)- Which antibody is specific for SLE but does not track with disease activity?
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Anti-Smith (anti-Sm) antibody- Which antibody is characteristic of drug-induced lupus?
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Anti-histone antibody- Name three drugs classically associated with drug-induced lupus.
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Hydralazine, procainamide, and isoniazid- What cardiac lesion in SLE features sterile vegetations on both sides of the valve leaflets?
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Libman-Sacks endocarditis- What is the most common and severe class of lupus nephritis?
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Diffuse proliferative glomerulonephritis- Name three antibodies associated with antiphospholipid syndrome.
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Anticardiolipin, lupus anticoagulant, and anti-beta2 glycoprotein I- Why can antiphospholipid syndrome cause a false-positive VDRL/RPR test?
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The antiphospholipid antibodies cross-react with the cardiolipin antigen used in the test- What are the two hallmark clinical features of antiphospholipid syndrome?
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Recurrent thrombosis and recurrent pregnancy loss- What inflamed synovial tissue erodes joints in rheumatoid arthritis?
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Pannus- Which antibody is most specific for rheumatoid arthritis?
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Anti-cyclic citrullinated peptide (anti-CCP)- What is rheumatoid factor?
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An IgM antibody directed against the Fc portion of IgG- Which finger joints are involved in rheumatoid arthritis, and which are spared?
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MCP and PIP joints are involved; DIP joints are spared
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