Microcytic, normocytic and macrocytic anemia evaluation, iron studies, hemolytic anemias, reticulocyte index, peripheral smear findings and treatments.
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- What is the normal reference range for mean corpuscular volume (MCV)?
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80 to 100 fL- Below what MCV value is an anemia classified as microcytic?
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Below 80 fL- Above what MCV value is an anemia classified as macrocytic?
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Above 100 fL- What is the first line treatment for iron deficiency anemia?
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Oral ferrous sulfate (iron supplementation)- In iron deficiency anemia, is serum ferritin low, normal, or high?
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Low- In iron deficiency anemia, is TIBC (total iron binding capacity) low, normal, or high?
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High- In iron deficiency anemia, is serum iron low, normal, or high?
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Low- In iron deficiency anemia, is transferrin saturation low, normal, or high?
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Low (typically under 20 percent)- In anemia of chronic disease, is serum ferritin typically low, normal, or high?
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Normal to high- In anemia of chronic disease, is TIBC typically low, normal, or high?
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Low- What liver produced hormone drives the iron sequestration seen in anemia of chronic disease?
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Hepcidin- What bone marrow finding defines sideroblastic anemia?
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Ringed sideroblasts (iron laden mitochondria encircling the nucleus)- What heavy metal toxicity is a classic acquired cause of sideroblastic anemia?
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Lead poisoning- What is the standard treatment for vitamin B12 deficiency with neurologic involvement?
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Intramuscular vitamin B12 injections- What ratio is used to help distinguish thalassemia trait from iron deficiency anemia?
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The Mentzer index (MCV divided by RBC count)
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