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Organic Chemistry · College

Organic Chemistry: Aromatic Chemistry and Electrophilic Substitution

Aromaticity criteria and electrophilic aromatic substitution mechanism steps and directing effects taught in a college organic chemistry sequence.

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What does 'cyclic' mean as an aromaticity requirement?
The molecule must contain a ring (a closed loop of atoms).
What does the 'planar' requirement mean for aromaticity?
All ring atoms must lie in the same plane so p orbitals can align.
What does 'fully conjugated' mean for an aromatic ring?
Every atom in the ring must have a p orbital available for overlap.
According to Huckel's rule, an aromatic ring must have ____ pi electrons.
4n+2
How many pi electrons does benzene have?
6 pi electrons
In Huckel's rule (4n+2) applied to benzene, what is the value of n?
n = 1
Define an antiaromatic compound.
A cyclic, planar, fully conjugated molecule with 4n pi electrons, which is destabilized.
Define a nonaromatic compound.
A molecule that fails at least one aromaticity requirement, such as not being planar or not fully conjugated.
Are all carbon-carbon bond lengths in benzene the same?
Yes, all six C-C bonds are equal in length, intermediate between single and double bonds.
What is the approximate resonance (stabilization) energy of benzene?
About 36 kcal/mol (150 kJ/mol)
Why does benzene resist typical alkene addition reactions?
Addition would destroy the ring's aromatic stabilization.
Why does benzene undergo substitution rather than addition with electrophiles?
Substitution replaces a hydrogen and restores aromaticity, unlike addition which would destroy it.
What is the first step of the electrophilic aromatic substitution mechanism?
The electrophile attacks the ring, forming a resonance-stabilized carbocation called the arenium ion.
What is another name for the arenium ion intermediate in EAS?
The sigma complex
What hybridization does the carbon attacked by the electrophile have in the arenium ion?
sp3

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