Organic Chemistry · MCAT

MCAT Organic Chemistry: Spectroscopy and Structure Determination

IR, NMR, and mass spectrometry interpretation concepts for determining organic molecule structure, tested on the MCAT.

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What molecular motions does IR spectroscopy detect?
Bond stretching and bending vibrations
What is the characteristic IR range for an O-H stretch in alcohols?
3200-3550 cm-1, broad
How does an amine N-H stretch differ in appearance from an alcohol O-H stretch in IR?
N-H is sharper and less broad than O-H
What is the typical IR range for a carbonyl (C=O) stretch?
1650-1750 cm-1, strong
What is the typical IR range for sp3 C-H stretches in alkanes?
2850-2960 cm-1
What is the characteristic IR range for a terminal alkyne C-H stretch?
About 3300 cm-1, sharp
What is the typical IR range for a C=C stretch in alkenes?
1620-1680 cm-1, weak to medium
What is the typical IR range for a C triple bond C stretch in alkynes?
2100-2260 cm-1, weak
What is the typical IR range for a nitrile C triple bond N stretch?
2200-2260 cm-1
Why does a carboxylic acid O-H stretch look different from an alcohol O-H stretch in IR?
It is much broader, spanning roughly 2500-3300 cm-1, due to strong hydrogen bonding
How does an ester C=O stretch frequency compare to a ketone C=O stretch?
Ester C=O appears at higher wavenumber, about 1735-1750 cm-1, than a ketone
Why does an amide C=O stretch appear at lower wavenumber than a ketone?
Resonance delocalization of the nitrogen lone pair lowers the C=O bond order
What is the fingerprint region of an IR spectrum?
The 1500-400 cm-1 region, unique to each molecule
What two peaks near 2720 and 2820 cm-1 are diagnostic for an aldehyde in IR?
A pair of weak C-H stretch bands from the aldehyde proton
What molecular property must change during a vibration for it to produce an IR absorption?
The dipole moment of the bond

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