Antibiotic selection, dosing, and monitoring for common infections as tested on the NAPLEX.
About this set
41 mixed cards for NAPLEX NAPLEX. It opens with "What is the current preferred vancomycin monitoring target for serious MRSA" and "What causes the vancomycin infusion reaction (flushing, pruritus, sometimes". More Healthcare and Nursing decks are listed below.
41 cards · mixed cards · AI-written, checked twice. Edit anything.
- What is the current preferred vancomycin monitoring target for serious MRSA infections (replacing trough-only monitoring)?
Show answer
AUC24/MIC ratio of at least 400- What causes the vancomycin infusion reaction (flushing, pruritus, sometimes hypotension) formerly called red man syndrome?
Show answer
Histamine release triggered by rapid IV infusion- Vancomycin's major dose-limiting toxicity affecting the kidneys is ____.
Show answer
nephrotoxicity- Name the two major toxicities associated with aminoglycosides such as gentamicin and tobramycin.
Show answer
Nephrotoxicity and ototoxicity- What aminoglycoside dosing strategy is preferred to reduce toxicity while exploiting their concentration-dependent killing?
Show answer
Extended-interval (once-daily) dosing- Which antibiotic class carries a black box warning for tendinitis and tendon rupture?
Show answer
Fluoroquinolones- Besides tendon rupture, name another black box warning associated with fluoroquinolones.
Show answer
Peripheral neuropathy- Fluoroquinolone doses should be separated in time from products containing which types of cations to avoid reduced absorption?
Show answer
Divalent and trivalent cations (calcium, magnesium, aluminum, iron, zinc)- Ciprofloxacin inhibits which cytochrome P450 enzyme, raising theophylline levels?
Show answer
CYP1A2- Why are fluoroquinolones generally avoided in children?
Show answer
Risk of cartilage damage (arthropathy)- The cross-reactivity concern between penicillins and cephalosporins is based mainly on similarity of what structural feature?
Show answer
The R1 side chain, not the beta-lactam ring itself- Which penicillin/beta-lactamase inhibitor combination provides coverage against Pseudomonas aeruginosa?
Show answer
Piperacillin-tazobactam- Which monobactam antibiotic is generally considered safe in patients with a penicillin allergy?
Show answer
Aztreonam- Aztreonam shares cross-reactivity risk with which cephalosporin because of a similar side chain?
Show answer
Ceftazidime- Which carbapenem carries the highest risk of lowering the seizure threshold?
Show answer
Imipenem-cilastatin
FlashKeepers