Depression, anxiety, and bipolar disorder drug therapy selection and monitoring parameters tested on the NAPLEX.
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- What is the first-line drug class for treating major depressive disorder (MDD)?
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SSRIs (selective serotonin reuptake inhibitors)
- Which SSRI has the longest half-life among the class?
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Fluoxetine
- Which SSRI has the most anticholinergic and sedating side effect profile?
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Paroxetine
- Which SSRI is most associated with GI side effects such as diarrhea?
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Sertraline
- What is the maximum recommended daily dose of citalopram due to QT prolongation risk?
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40 mg per day (20 mg per day in patients over 60 or with hepatic impairment)
- What side effect is commonly shared by SSRIs and SNRIs as a class?
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Sexual dysfunction
- Serotonin syndrome presents with altered mental status, autonomic instability, and ____.
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neuromuscular abnormalities such as clonus, hyperreflexia, and tremor
- Venlafaxine and duloxetine belong to which antidepressant class?
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SNRIs (serotonin-norepinephrine reuptake inhibitors)
- What vital sign should be monitored with venlafaxine due to a dose-dependent effect?
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Blood pressure (can cause hypertension at higher doses)
- Bupropion should be avoided in patients with which two conditions?
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Seizure disorder and eating disorders (such as bulimia)
- What are the two most common side effects of mirtazapine?
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Weight gain and sedation
- Why must patients on MAOIs avoid tyramine-rich foods?
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To prevent a hypertensive crisis
- How many weeks does it typically take to see the full effect of an antidepressant?
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4 to 6 weeks
- What drug class is used first-line for short-term relief of acute anxiety symptoms?
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Benzodiazepines
- Which anxiolytic has a delayed onset of 2 to 4 weeks and low abuse potential?
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Buspirone