High-yield drug-drug interactions and serious adverse effect recognition tested on the NAPLEX, distinct from the disease-state focus of the pharmacotherapy deck.
44 cards · mixed cards · AI-written, checked twice. Edit anything.
- What is the main risk of combining warfarin with NSAIDs?
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Increased bleeding risk (additive antiplatelet and GI effects)- How does amiodarone affect warfarin therapy?
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It inhibits CYP2C9, increasing INR and bleeding risk- Why does combining a statin with clarithromycin raise myopathy risk?
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Clarithromycin inhibits CYP3A4, raising statin blood levels- What electrolyte abnormality can result from combining an ACE inhibitor with a potassium-sparing diuretic?
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Hyperkalemia- Combining an SSRI with an MAOI can cause what life-threatening syndrome?
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Serotonin syndrome- What serious interaction can occur if tramadol is combined with an SSRI?
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Serotonin syndrome- Why is combining linezolid with an SSRI dangerous?
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Linezolid has weak MAOI activity, risking serotonin syndrome- What dietary interaction can trigger a hypertensive crisis in a patient on MAOIs?
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Eating tyramine-rich foods (aged cheese, cured meats)- Why should sildenafil never be combined with nitrates?
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Risk of severe, life-threatening hypotension- How does amiodarone affect digoxin levels?
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It inhibits P-glycoprotein, increasing digoxin levels and toxicity risk- Digoxin toxicity classically presents with ____, arrhythmias, and nausea.
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visual disturbances such as yellow-green halos- What serious GI adverse effect is associated with clindamycin use?
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Clostridioides difficile colitis- What musculoskeletal adverse effect is a black box warning for fluoroquinolones?
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Tendon rupture (especially the Achilles tendon)- Besides tendon rupture, what cardiac risk do fluoroquinolones and macrolides share?
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QT interval prolongation- Why does combining methotrexate with NSAIDs increase toxicity risk?
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NSAIDs reduce renal clearance of methotrexate, raising its levels
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