High-yield drug-drug interactions and serious adverse effect recognition tested on the NAPLEX, distinct from the disease-state focus of the pharmacotherapy deck.
44 cards · basic cards · AI-written, checked twice. Edit anything.
- What is the main risk of combining warfarin with NSAIDs?
- Increased bleeding risk (additive antiplatelet and GI effects)
- How does amiodarone affect warfarin therapy?
- It inhibits CYP2C9, increasing INR and bleeding risk
- Why does combining a statin with clarithromycin raise myopathy risk?
- Clarithromycin inhibits CYP3A4, raising statin blood levels
- What electrolyte abnormality can result from combining an ACE inhibitor with a potassium-sparing diuretic?
- Hyperkalemia
- Combining an SSRI with an MAOI can cause what life-threatening syndrome?
- Serotonin syndrome
- What serious interaction can occur if tramadol is combined with an SSRI?
- Serotonin syndrome
- Why is combining linezolid with an SSRI dangerous?
- Linezolid has weak MAOI activity, risking serotonin syndrome
- What dietary interaction can trigger a hypertensive crisis in a patient on MAOIs?
- Eating tyramine-rich foods (aged cheese, cured meats)
- Why should sildenafil never be combined with nitrates?
- Risk of severe, life-threatening hypotension
- How does amiodarone affect digoxin levels?
- It inhibits P-glycoprotein, increasing digoxin levels and toxicity risk
- Digoxin toxicity classically presents with ____, arrhythmias, and nausea.
- visual disturbances such as yellow-green halos
- What serious GI adverse effect is associated with clindamycin use?
- Clostridioides difficile colitis
- What musculoskeletal adverse effect is a black box warning for fluoroquinolones?
- Tendon rupture (especially the Achilles tendon)
- Besides tendon rupture, what cardiac risk do fluoroquinolones and macrolides share?
- QT interval prolongation
- Why does combining methotrexate with NSAIDs increase toxicity risk?
- NSAIDs reduce renal clearance of methotrexate, raising its levels