Dangerous combinations such as warfarin interactions, serotonin syndrome pairs, QT prolongation, grapefruit effects and CYP inhibitors and inducers.
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- What serious risk increases when warfarin is combined with aspirin?
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Increased bleeding risk (anticoagulant plus antiplatelet effect)- How does amiodarone affect warfarin therapy?
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It inhibits CYP2C9, raising INR and bleeding risk- Why does metronidazole increase warfarin's effect?
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It inhibits warfarin metabolism, raising INR and bleeding risk- What happens when fluconazole is given with warfarin?
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Fluconazole inhibits CYP2C9, significantly increasing INR- Why can eating large amounts of vitamin K-rich leafy greens reduce warfarin's effectiveness?
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Vitamin K counteracts warfarin's anticoagulant mechanism, lowering INR- How does rifampin affect warfarin dosing needs?
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Rifampin induces liver enzymes, lowering warfarin levels and INR, often requiring a higher dose- What interaction risk does trimethoprim-sulfamethoxazole pose with warfarin?
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It inhibits warfarin metabolism, increasing bleeding risk- What dangerous syndrome can result from combining an SSRI with an MAOI?
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Serotonin syndrome- Why is tramadol risky with SSRIs?
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Both increase serotonin activity, raising serotonin syndrome risk- What risk arises from combining triptans with SSRIs?
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Serotonin syndrome- Why is linezolid dangerous with SSRIs?
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Linezolid has MAOI activity, risking serotonin syndrome- Why can St. John's Wort be dangerous with SSRIs?
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It increases serotonergic activity, risking serotonin syndrome- What classic drug combination causes severe hyperpyrexia and serotonin syndrome?
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Meperidine with an MAOI- Why is dextromethorphan risky in patients taking SSRIs?
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It has serotonergic activity and can trigger serotonin syndrome- Why is methadone combined with other QT-prolonging drugs especially dangerous?
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Additive QT prolongation increases torsades de pointes risk
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