Substance intoxication and withdrawal management plus personality disorder cluster recognition scenarios tested on USMLE Step 2 CK.
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- How soon after the last drink do alcohol withdrawal symptoms typically begin?
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6 to 24 hours
- In alcohol withdrawal, during what time window do withdrawal seizures most commonly occur?
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12 to 48 hours after the last drink
- In alcohol withdrawal, during what time window does delirium tremens typically appear?
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48 to 96 hours after the last drink
- What are the key features of delirium tremens?
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Autonomic instability, severe confusion, and visual or tactile hallucinations
- What is the first-line drug class for treating alcohol withdrawal?
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Benzodiazepines
- What is the classic triad of Wernicke encephalopathy?
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Confusion, ataxia, and ophthalmoplegia
- In a malnourished alcoholic patient, ____ should be given before glucose to avoid precipitating Wernicke encephalopathy.
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thiamine
- What is the hallmark feature distinguishing Korsakoff syndrome from Wernicke encephalopathy?
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Anterograde amnesia with confabulation
- What are the characteristic symptoms of opioid withdrawal?
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Diarrhea, rhinorrhea, piloerection, yawning, and muscle aches
- Which two medications are used for medication-assisted treatment of opioid use disorder?
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Methadone and buprenorphine
- What is the classic triad of opioid overdose?
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Miosis (pinpoint pupils), respiratory depression, and CNS depression
- What is the antidote used to reverse opioid overdose?
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Naloxone
- What is the major medical risk of untreated benzodiazepine withdrawal?
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Life-threatening seizures
- What is the recommended approach to managing sedative-hypnotic (e.g., benzodiazepine) withdrawal?
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A gradual, tapered dose reduction
- What are the signs of cocaine or amphetamine intoxication?
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Euphoria, tachycardia, hypertension, and pupillary dilation