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Perfusion · ABCP CCP

Perfusion: Mechanical Circulatory Support

Intra-aortic balloon pumps, ECMO, and ventricular assist devices, including indications and basic management principles.

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What is the primary mechanism by which an intra-aortic balloon pump (IABP) augments the circulation?
Counterpulsation: the balloon inflates during diastole to boost coronary perfusion and deflates just before systole to reduce afterload
Where is the tip of a correctly positioned intra-aortic balloon typically located?
In the descending thoracic aorta, just distal to the origin of the left subclavian artery
What gas is used to inflate an intra-aortic balloon?
Helium, because of its low viscosity and rapid diffusion characteristics
What ECG or pressure waveform feature is commonly used to time IABP inflation?
The dicrotic notch on the arterial pressure waveform, corresponding to aortic valve closure
What hemodynamic effect does correctly timed IABP deflation have just before systole?
It reduces left ventricular afterload, lowering myocardial oxygen demand and improving forward stroke volume
Name a major contraindication to intra-aortic balloon pump use.
Significant aortic insufficiency (or severe aortic disease such as dissection or significant aneurysm)
What does the acronym ECMO stand for?
Extracorporeal membrane oxygenation
What are the two main configurations of ECMO based on cannulation?
Venovenous (VV) ECMO and venoarterial (VA) ECMO
What is the primary purpose of venovenous (VV) ECMO?
Providing respiratory support (gas exchange) in patients with severe respiratory failure but adequate cardiac function
What is the primary purpose of venoarterial (VA) ECMO?
Providing both cardiac and respiratory support in patients with combined cardiac and respiratory failure or cardiogenic shock
Why does VV ECMO not provide direct hemodynamic (cardiac output) support?
Blood is returned to the venous system rather than the arterial system, so it does not bypass or directly assist the failing heart
What complication is specific to peripheral VA ECMO where the native heart still ejects some blood against retrograde arterial flow?
Differential hypoxia (Harlequin syndrome), where poorly oxygenated blood from the native heart preferentially perfuses the upper body
What is often placed distal to a femoral arterial ECMO cannula to prevent limb ischemia?
A distal limb reperfusion cannula (distal perfusion catheter)
What is the general purpose of a ventricular assist device (VAD)?
Mechanically augmenting or replacing the pumping function of a failing ventricle to maintain adequate systemic or pulmonic circulation
What are the three general clinical intent categories for VAD implantation?
Bridge to transplant, bridge to recovery, and destination therapy

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