Chemotherapy safe handling, agents and toxicities, extravasation, neutropenia, nausea, mucositis, pain and survivorship care.
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- What is a vesicant chemotherapy agent?
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A drug that causes tissue damage or blistering if it leaks outside the vein- What is extravasation?
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Leakage of a vesicant or irritant drug from the vein into surrounding tissue- First nursing action when extravasation is suspected
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Stop the infusion immediately- Antidote used for anthracycline (e.g., doxorubicin) extravasation
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Dexrazoxane- Major dose-limiting toxicity of doxorubicin
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Cardiotoxicity (cardiomyopathy)- Major toxicity of vincristine
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Peripheral neuropathy- Major toxicity of cisplatin
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Nephrotoxicity- Major toxicity of bleomycin
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Pulmonary fibrosis- Major toxicity of cyclophosphamide
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Hemorrhagic cystitis- Drug given to protect the bladder from cyclophosphamide/ifosfamide toxicity
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Mesna- Rescue drug given after high-dose methotrexate
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Leucovorin (folinic acid)- What is the chemo nadir?
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The lowest point blood counts drop to after chemotherapy, usually 7 to 14 days after treatment- An absolute neutrophil count below ____ cells/mm3 is classified as severe neutropenia.
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500- Define neutropenic fever
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A single temperature of 38.3C (101F) or higher, or 38C sustained for one hour, in a neutropenic patient- Single most effective measure to prevent infection in a neutropenic patient
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Hand hygiene
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