HIV testing, antiretroviral classes, CD4 thresholds for prophylaxis, opportunistic infection organisms, PrEP and PEP.
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- What blood test is recommended as the initial screening test for HIV infection?
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A 4th generation antigen/antibody combination immunoassay
- Which specific HIV antigen does the 4th generation screening test detect in addition to antibodies?
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p24 antigen
- About how long is the window period for a 4th generation HIV antigen/antibody test?
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About 2 to 4 weeks after exposure
- Which older HIV confirmatory test has largely been replaced in current testing algorithms?
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Western blot
- What test now serves as the HIV confirmatory test in place of Western blot?
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HIV-1/HIV-2 antibody differentiation immunoassay
- Which test best detects acute HIV infection before antibodies have formed?
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HIV RNA (viral load) test
- At what CD4 count should prophylaxis against Pneumocystis jirovecii pneumonia (PCP) begin?
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CD4 count less than 200 cells/mcL
- What is the first-line drug for PCP prophylaxis?
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Trimethoprim-sulfamethoxazole (TMP-SMX)
- At what CD4 count should prophylaxis against Mycobacterium avium complex (MAC) begin?
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CD4 count less than 50 cells/mcL
- What drug is used for MAC prophylaxis in advanced HIV?
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Azithromycin, given weekly
- At what CD4 count should toxoplasmosis prophylaxis be considered in a Toxoplasma IgG-positive patient?
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CD4 count less than 100 cells/mcL
- What is an alternative PCP prophylaxis option for a patient with a sulfa allergy?
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Dapsone, atovaquone, or aerosolized pentamidine
- Which organism causes Pneumocystis pneumonia in AIDS patients?
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Pneumocystis jirovecii, a fungus
- Which organism causes toxoplasma encephalitis in AIDS patients?
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Toxoplasma gondii, a protozoan parasite
- Which virus causes retinitis in patients with advanced AIDS?
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Cytomegalovirus (CMV)