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Biochemistry · MCAT

MCAT Biochemistry: Lipids and Membrane Structure

Lipid classification and cell membrane structure and transport concepts tested on the MCAT.

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What is a fatty acid?
A carboxylic acid with a long hydrocarbon tail.
What distinguishes a saturated fatty acid from an unsaturated one?
A saturated fatty acid has no carbon-carbon double bonds; an unsaturated one has at least one.
Why do unsaturated fatty acids typically have a lower melting point than saturated ones?
Double bonds create kinks that prevent the tails from packing tightly together.
What are the two essential fatty acids the human body cannot synthesize?
Linoleic acid and alpha-linolenic acid.
In an omega-3 fatty acid, where is the first double bond located?
At the third carbon counting from the methyl (omega) end.
What three components make up a triacylglycerol?
One glycerol molecule joined to three fatty acids.
What type of chemical bond links fatty acids to glycerol in a triglyceride?
An ester bond.
What is the main biological role of triacylglycerols?
Long term energy storage.
What does the term amphipathic mean for a membrane lipid?
It has both a hydrophilic (polar) region and a hydrophobic (nonpolar) region.
What are the four main components of a glycerophospholipid?
A glycerol backbone, two fatty acid tails, a phosphate group, and a polar head group.
Which part of a phospholipid faces the aqueous environment in a bilayer?
The polar phosphate head group.
What backbone do sphingolipids use instead of glycerol?
Sphingosine, an amino alcohol.
What is sphingomyelin?
A sphingolipid with a phosphocholine head group, abundant in myelin sheaths.
What is a glycolipid?
A lipid with an attached sugar group, found on the outer leaflet of the plasma membrane and involved in cell recognition.
What distinguishes a ganglioside from a cerebroside?
A ganglioside has a complex oligosaccharide head containing sialic acid; a cerebroside has a single simple sugar.

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